Description
Our client is an exciting start-up still in stealth mode, focusing on the immunotherapy market. Currently building out their cell sciences team, they have an exciting opportunity for an Associate Scientist to join their Multi-Omics team. As an Associate Scientist, you will bring existing experience in multi-omics, analytics and target discovery.
The Role:
This position focuses on supporting and executing multi-omics workflows as part of a collaborative team. The goal is to develop the next generation of mammalian expression systems and cell lines to enable efficient pharmaceutical bioprocesses and cost-effective immunotherapeutics.
Key Responsibilities:
- Design and contribute to the generation and interpretation of multi-omics datasets to advance cell line characterization and target discovery pipelines.
- Develop, optimize, and implement high-throughput sample preparation methods, including next-generation sequencing (NGS), transcriptomics, and other advanced analytical assays to accelerate research.
- Perform mammalian suspension cell culture and related techniques, such as passaging, banking, nucleofection, and genotyping, as well as assays including western blotting and FACS.
- Prepare and maintain key project deliverables, including SOPs, training documents, and COSHH forms.
- Train team members to a high level of competency to ensure data integrity.
- Accurately document research findings in laboratory notebooks.
- Present findings regularly in group meetings and provide updates to project teams and stakeholders.
- Contribute to routine laboratory maintenance, including equipment care, cleaning schedules, and consumables management.
- Share responsibility for out-of-hours cell culture maintenance.
- Adhere to and promote laboratory health, safety, and quality procedures.
- Assist with laboratory risk assessments and ensure compliance with safety protocols.
- Maintain project confidentiality and ensure adherence to protocols.
- Stay updated on new technologies and relevant scientific developments to identify potential improvements and cost-reduction opportunities.
Required Qualifications & Experience
- MSc in Biochemistry, Molecular Biology, or a related field, with 3+ years of industry experience, OR
- PhD in a relevant field with 1+ years of industry experience.
- Proficiency in generating and working with large datasets, including transcriptomic, proteomic, or metabolomic datasets.
- Experience developing high-throughput methods (e.g., HT NGS) for automated target discovery pipelines.
- Familiarity with bioprocess-relevant cell lines such as CHO or HEK293 for monoclonal antibody production and characterization.
- Expertise in mammalian cell culture techniques, including passaging, banking, transfection, nucleofection, and genotyping.
- Experience with mammalian cell line development, including GM/GE cell lines, single-cell cloning, and CRISPR/ORF library screens.
- Skilled in molecular biology techniques, including FACS, qRT-PCR, Western blot, and ELISA.
- Strong experimental design and troubleshooting skills.
- Proven ability to work independently and collaboratively within a team.
- Experience planning experiments and meeting project timelines.
- Strong numeracy, computer literacy, and communication skills.
- Desirable Experience:
- Familiarity with analytical methods such as HPLC/UPLC and LC-MS for antibody characterization.
- Knowledge of experimental techniques such as metabolic flux analysis (MFA).
- Experience applying Design of Experiments (DOE) principles to optimize experimental designs.
Key Skills and Attributes:
- Innovative and solutions-oriented mindset.
- Advanced problem-solving abilities.
- Self-motivated with a proactive approach.
- Results-driven with a commitment to high-quality outcomes.
- Reliable and organized, with the ability to multitask effectively.
- Strong time management and organizational skills.
- Excellent written and verbal communication skills.
- Team-oriented and adaptable within a dynamic, multidisciplinary environment.
This role offers an exciting opportunity to contribute to ground breaking research and development in the field of bioprocessing and immunotherapeutics.
£35k - £38k – Oxford
